Key Features

? Semi-automated sample delivery with BI-DirectFlow? technology

For ultra-fast kinetics, distinction/extraction of secondary effects, and higher quality results

? Innovative multi-module design

Provides users with maximum flexibility to choose amongst various analysis modules for diverse applications

? Compatible with electrochemistry and chemical vapor applications

Allows for electrochemical SPR studies, chemical vapor detection, gas chemical sensor research, and fundamental solid-gas interface studies (chemical vapor applications exclusive to BI-3000G model)

? Two-channel SPR detection module

Covers wide SPR angle range for measuring SPR shift in liquid and gas phases. Also capable of accurate background and reference subtraction.

? Single and dual channel flow modes

Allows for more experimental options and enhanced data quality

? Wide dynamic range and high sensitivity

High sensitivity (<10-5 degrees) for both large and small molecules (<100 Daltons) enables users to measure binding constants down to a few pM-1

? Broad response time

For slow (hours) and fast (< 0.5 ms) kinetic processes

Analysis Modules

Included:

BI-DirectFlow? Module 

for advanced two-channel ultra-fast kinetics research

Gas SPR Module 

for gas phase and chemical vapor SPR research

*included in BI-3000G model only

Optional Accessories:

EC-DualFlow? Module 

for advanced two-channel electrochemical (EC) flow SPR research

EC-SPR Module 

for electrochemical (EC) SPR research

BI Sensor Chips

with high uniformity for reproducible SPR research

BI-SPR System Specifications:

SPR Base Station 

Two-channel SPR Detection Unit

With differential detection electronics for high sensitivity and fast detection

   Broad detection range for measuring SPR binding in liquid and gas mediums

   Accurate background and reference subtraction

   Broad response window for slow and fast kinetics analysis

   Viewable SPR profile for SPR quality and chip evaluation

   Thermal isolation technology to minimize thermal drift

Versatile in Application

One instrument for numerous applications

   Interchangeable analysis modules for different research needs

   Accessible detection area and auxiliary data IO ports to facilitate project integration

   Small footprint to save valuable lab space

   USB connectivity for convenient transportability

Fluid Handling

 Semi-automated sample delivery with BI-DirectFlow?

For two-channel precision sample delivery

   Near-zero sample dispersion for fast kinetics and high resolution binding analysis

   Single and serial flow modes

   Continuous flow stream for uninterrupted binding studies

   Zero-dead volume injection valves for negligible sample carry over

   HPLC-type components for convenient and low cost maintenance

Precision Syringe Pump 

Two-channel programmable syringe pump for uniform continuous flow

   Wide flow range from tens of nanoliters to milliliters a minute(depending upon syringe size)

   Accurate, precise, and steady flow resulting in stable baselines and high quality data

   Quiet and easy operation

Control System

 Control/Analysis Software

Powerful and easy-to-use software package

   Collect SPR data in real-time

   Programmable injection timers for accurate sample delivery

   Easily manage and/or overlay multiple data files

   Smart Wizards to guide user through instrument operation

   Powerful analysis tools to evaluate binding interactions, i.e. affinity, kinetics, concentration, and more

   Tools to compensate for bulk refractive index shift, non-specific adsorption, mass limited transport, noise, and more

   Select amongst various SPR operational modes for optimized performance, i.e. flow injection, gas, and EC

Computer 

PC with pre-installed BI software package

   Windows 7 operating system

   Ethernet connectivity (direct on-line customer support available)

   USB connectivity to BI-SPR instruments for transportability

Applications:

Life Science

Our Flow injection technique and analysis modules can help you with drug discovery and development, protein-protein/ protein-DNA/ protein-drug interaction studies, gene assays, immunosensing, and more.

Electrochemistry

Our Electrochemical SPR technique and analysis modules can help you with a variety of electro-analytical applications such as anodic stripping analyses, electropolymerization, electrodeposition, redox-related conformational change, and more. 

Chemical Vapor Sensing

Our Gas Phase SPR technique and analysis modules can help you study fundamental solid-gas interface interactions, detect toxic molecules in the environment, perform various chemical analyses for medical research, and more.

Environment, Food & Beyond

Our BI-SPR techniques can help you with broader applications such as food safety, quality control, environmental monitoring, or the development of new high-performance and coupled SPR techniques.