Acid-sensing ion channels (ASICs) are voltage independent cation channels, which are expressed in both central and peripheral neurons.[1] Four genes that encode six ASIC subunits have been identified in mammals (ASIC1a, ASIC1b, ASIC2a, ASIC2b, ASIC3
Monoclonal antibody (mAb) therapies have become established methods for treating cancer, autoimmune disorders, asthma and many other diseases. MAb drugs represent approximately half of the total sales of all biopharmaceutical products (1) and over 6
G-protein coupled receptors (GPCR) are integral membrane proteins that transmit signals from external stimuli to the cell interior. They play key roles in many cellular processes, such as sensorial, hormonal, metabolic, immunological, and neurotrans
Membrane proteins are involved in many biological processes, such as signaling between cell’s internal and external environments, transport of ions and molecules and catalysis of chemical reactions [1] and they are also the targets of more than 60%
SPRm 200 System is the world’s first commercial Surface Plasmon Resonance Microscopy (SPRM). It combines the high spatial resolution of optical microscopy with the powerful sensing capability of SPR, making it possible to measure the binding of mole
Streptavidin (SA) sensor chips are commonly used for kinetic interactions of biotinylated ligands. Streptavidin is a tetrameric molecule with an extremely high affinity towards biotin and， because of its binding capacity, reproducibility and chemica
Surface Plasmon Resonance (SPR) is a powerful technique for measuring the binding kinetics of biomolecular interactions in a real-time and label-free manner [1]. In traditional SPR assays, the target molecule is extracted and purified fr
Protein-protein interactions are essential for many biochemical transformations and cellular processes. However, traditional methods of detecting these interactions are often times qualitative and provide little information (1). Alternatively, more